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dc.contributor.authorZito Marinosci, Geremia
dc.contributor.authorDe Robertis, Edoardo
dc.contributor.authorDe Benedictis, Giuseppe
dc.contributor.authorPiazza, Ornella
dc.date.accessioned2013-05-29T10:45:31Z
dc.date.available2013-05-29T10:45:31Z
dc.date.issued2012
dc.identifier.citationZito Marinosci G, De Robertis E, De Benedictis G, Piazza O. Dopamine use in intensive care: are we ready to turn it down? Translational Medicine @ UniSa 2012;4(11):90-94en_US
dc.identifier.issn2239-9747en_US
dc.identifier.urihttp://hdl.handle.net/10556/641
dc.description.abstractDopamine is still frequently used as a first line vasopressor agent in hypotensive patients, when physicians are afraid of noradrenaline and believe that dopamine, with its β and α, inotrope and vasopressor effects, may be helpful. Evidence exists that it does not offer protection from renal failure, even if at low doses (0, 3-5 mcg/Kg/min) it may exert its effects on D1 and D2 receptors resulting in natriuresis and renal vasodilation, augmentation in renal blood flow, and diuresis. The effects of dopamine on gastrointestinal system and splanchnic perfusion in critical care patients are even more controversial, since they seem to be at least partially dependent on the initial fractional splanchnic blood flow. Dopamine may exert deleterious effects on respiratory function, by impairing the ventilatory drive response to hypoxemia and hypercapnia and reducing arterial oxygen saturation through a regional ventilation/perfusion mismatching. Dopamine seems to affect the cellular mediated mechanism of the immune function directly by its action on receptors located on immune system cells and indirectly altering the hormonal response regulating immune response. In this paper, the use of low dose dopamine is discussed in the intensive care perspective.en_US
dc.format.extentP. 90-94en_US
dc.language.isoenen_US
dc.sourceUniSa. Sistema Bibliotecario di Ateneoen_US
dc.subjectDopamineen_US
dc.subjectICUen_US
dc.subjectVasopressoren_US
dc.subjectShocken_US
dc.titleDopamine use in intensive care: are we ready to turn it down?en_US
dc.typeArticleen_US
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