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Translational pharmacogenomics: a study of warfarin dosing
(Universita degli studi di Salerno, 2016-04-21)
Warfarin is one of the most commonly used oral anticoagulants worldwide and is highly efficacious for the treatment and prevention of thromboembolic disorders. However, due to its narrow therapeutic index, large inter-individual ...
Studio delle relazioni tra alimentazione e stati fisiopatologici mediante un approccio di biologia dei sistemi
(Universita degli studi di Salerno, 2016-09-30)
Lifestyle and food choices have an important role in the onset and in the prevention of
some diseases. The assumption of some food-related molecules can have different
effects on human health; for example, the antioxidants ...
Neurodegeneration in Chronic Kidney Disease: role of neuroinflammation and uremic toxins
(Universita degli studi di Salerno, 2017-03-28)
Neuroinflammation and oxidative stress have been recognized as common aspects in neurodegenerative diseases. Although the inflammatory process may induce beneficial effects, such as the elimination of the pathogen, ...
Studio dei meccanismi molecolari alla base dell’azione dei microRNA in processi patologici
(Universita degli studi di Salerno, 2016-05-10)
My research project concerns the study of the molecular mechanisms involving microRNAs (miRNAs) in pathological processes such as tumors and cardiovascular diseases. miRNAs are small non-coding RNAs (sncRNAs) acting by ...
Design and synthesis of modulators of apoptotic activity
(Universita degli studi di Salerno, 2016-03-23)
p53 is a transcription factor with tumour suppressor properties, which is able to induce mitochondrial apoptosis independently of its transcriptional activity. Analogues of the spiro[imidazo[1,5-c] thiazole-3,3′-indoline] ...
La Pentraxina 3: un potenziale marcatore di danno endoteliale nell’ipertensione arteriosa
(Universita degli studi di Salerno, 2016-04-26)
Background - The pentraxin 3 (PTX3) is a protein of the acute phase of inflammation
which represents the prototype of the long pentraxins. In the last years, numerous
studies have correlated the elevated plasma levels ...
Essential Infantile Esotropia with Inferior Oblique hyperfunction and Lateral Recti pseudoparalysis: long term follow-up of 6 muscles approach
(Universita degli studi di Salerno, 2016-04-21)
AIM: Analysis of long-term follow-up (3 months, 2 years, 5 years and 10 years) in Infantile Esotropia patients (IE), after a 6 muscles approach.
METHODS: A 6 muscles approach in IE has been evaluated in patients with ...
Rischio clinico, gestione del rischio e sue implicazioni. Un aspetto della medicina traslazionale
(Universita degli studi di Salerno, 2017-06-05)
This thesis is based on the awareness that prevention in the ethical and vocational training of health workers is extremely important, above all the one concerned with the clinical risk as well as a competent and intelligent ...
Design, synthesis and biological evaluation of new anticancer and/or anti-inflammatory agents
(Universita degli studi di Salerno, 2017-03-22)
One of the main goal of modern medicinal chemistry is the development of new agents able to modulate biological targets involved in inflammation and cancer processes. In this context, my PhD project was focused on the ...
Analisi funzionale del gene UVR8 e suo ruolo nella risposta delle piante a stress ambientali
(Universita degli studi di Salerno, 2015-07-16)
Plants are sessile organisms and, therefore, are continuously subjected to environmental sub-optimal or stressful conditions. In an arid environment plants are challenging multiple stresses, such, as water shortage, excessive ...