Browsing Scienze del farmaco by Title
Now showing items 12-22 of 22
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In vitro effects of bioactive extracts of local Italian cultivars: from molecular mechanisms to potential nutraceutical applications for consumers’ well-being
(Universita degli studi di Salerno, 2017-03-31)Phytochemicals are non-nutritional compounds, naturally present in food and beverages, which exert beneficial effects on human health. The present Doctorate Thesis evaluates the biological properties of bioactive ... -
Molecular basis of cardiomiopathy
(Universita degli studi di Salerno, 2018-04-05)The normal heart rhythm is guaranteed by an important intercellular junctions system, named Gap Junction (GJs). Each GJs consists of two units called connexons formed by six specific trans-membrane proteins named connexins ... -
Neurodegeneration in Chronic Kidney Disease: role of neuroinflammation and uremic toxins
(Universita degli studi di Salerno, 2017-03-28)Neuroinflammation and oxidative stress have been recognized as common aspects in neurodegenerative diseases. Although the inflammatory process may induce beneficial effects, such as the elimination of the pathogen, ... -
NMR-based metabolomic analysis of biological fluids to monitor relevant unsolved diseases
(Universita degli studi di Salerno, 2017-03-30)Metabolomics and metabonomics encompass the comprehensive profiling of multiple metabolite concentrations and their cellular and systemic fluctuations in response to drugs, diet, lifestyle, environment, stimuli and genetic ... -
PGI products of Campania region: chemical and biological investigation of edible parts and by-products as potential sources of functional ingredients for herbal, nutraceutical and cosmetic formulations.
(Universita degli studi di Salerno, 2018-05-05)This project is addressed to the definition of the chemical profile of selected PGI products of Campania region and related byproducts to highlight the presence of phytochemicals with health benefits. The species studied ... -
Role of CD73 - A2A/A2B receptors axis in cancer
(Universita degli studi di Salerno, 2018-04-05)The adenosinergic pathway plays a critical role in cancer development and progression, as well as in drug resistance to chemotherapy and/or targeted-therapy. The goal of this PhD thesis was to investigate and fully ... -
Role of TFF1 in tumor progression
(Universita degli studi di Salerno, 2017-03-31)Trefoil Factor 1 (TFF1) is a small secreted protein, belonging to the trefoil factor family, characterized by a conserved “trefoil domain” containing six cysteine residues that form a three loop disulphide structure. It ... -
Structural investigation of gp36-MPER in membrane mimicking systems
(Universita degli studi di Salerno, 2019-05-07)FIV is a lentivirus that resembles the Human Immunodeficiency Virus (HIV). The lentiviral envelope glycoproteins (gp41 in HIV and gp36 in FIV) mediate virus entry by interacting with specific receptors present at the cell ... -
Target-based study to identify new bioactive diterpenes
(Universita degli studi di Salerno, 2019-04-16)Target identification and mechanism of action studies of plant-derived compounds play a critical role in drug discovery. The knowledge of the bioactivity of natural compounds can lead to a number of advantages: first of ... -
Technologies for the development of health products based on up-cycling of agro-food by-products
(Universita degli studi di Salerno, 2019-04-12)The agro-industrial processing produces large volumes of wastes and by-products. In recent years, wastes and by-products have attracted attention as an excellent renewable source of active compounds with beneficial effects ... -
The Winnie-APCmin as an innovative tool to investigate the axis between inflammation and colorectal cancer
(Universita degli studi di Salerno, 2019-05-07)During these last three yeas of PhD we aimed to create a new murine model of spontaneous inflammatory-induced colorectal cancer a combining the genetic susceptibility of the APCMin model and the chronic intestinal inflammation ...
