Sfoglia Translational Medicine @ UniSa per Data di Pubblicazione
Items 21-40 di 284
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An engineering approach to biomedical sciences: advanced testing methods and pharmacokinetic modeling
(2012)In this paper, the philosophy of a research in pharmacology field, driven by an engineering approach, was described along with some case histories and examples. The improvement in the testing methods for pharmaceutical ... -
Prognostic differences between VAP caused by Acinetobacter baumannii and VAP caused by other microorganisms
(2012)Nosocomial infection, in particular pneumonia, is an important risk factor for hospital mortality and morbidity. Acinetobacter baumannii is a common multi-resistant microorganism responsible of Ventilator Associated Pneumonia ... -
Estrogens and neuropeptides in postmenopausal women: un update
(2012)Menopause is characterized by depletion of ovarian follicles, a reduction of ovarian hormones to castrate levels and elevated levels of serum gonadotropins from the anterior pituitary gland. Although this process has ... -
A polymorphism within the promoter of the dopamine receptor D1 (DRD1 -48A7G) associates with impaired kidney function in white hypertensive patients
(2012)Dopamine DRD1 receptor regulates renal function and vascular resistance. It plays a role in the pathogenesis of hypertension in animal models. In humans, the DRD1 gene presents a A-48G polymorphism associated to hypertension ... -
Economic evaluation of “pulse dose” radiofrequency in the treatment of occipital neuralgia headache
(2012)Headache occipital neuralgia is an example of pain-disease for which treatment both pharmacological protocols and invasive methods are used. Among the latter, the RF (Radiofrequency) pulse-dose has been of interest for the ... -
1,4-Dihydropyridines: the multiple personalities of a blockbuster drug family
(2012)More than 40 years after their introduction in therapy, 1,4-dihydropyridines (DHPs) are still amongst the most prescribed drugs in the world. Though they all share a similar mechanism of action blocking L-type voltage-gated ... -
An engineering approach to biomedical sciences: advanced strategies in drug delivery systems production
(2012)Development and optimization of novel production techniques for drug delivery systems are fundamental steps in the “from the bench to the bedside” process which is the base of translational medicine. In particular, in the ... -
Exercise training in aging and diseases
(2012)Sedentary lifestyle along with high blood pressure, abnormal values for blood lipids, smoking, and obesity are recognized risk factors for cardiovascular diseases and for many other chronic diseases, such as ... -
Treatment of clavicle fractures
(2012)Clavicle fractures are very common injuries in adults (2-5%) and children (10-15%) (1) and represent the 44-66% of all shoulder fractures (2). Despite the high frequency the choice of proper treatment is still a challenge ... -
Anatomy and surgery of the endoscopic endonasal approach to the skull base
(2012)The midline skull base is an anatomical area, which extends from the anterior limit of the anterior cranial fossa down to the anterior border of the foramen magnum. For many lesions of this area, a variety of skull base ... -
The clinical significance of delirium in the intensive care unit
(2012)Delirium is prevalent among intensive care unit patients. It prolongs length of stay, increases costs, and is independently associated with higher mortality rates. While its specific biological pathways are largely unknown, ... -
Posttranscriptional gene regulation: novel pathways for glucocorticoids? Anti-inflammatory action
(2012)Posttranscriptional gene regulation (PTR) is a fundamental biological process that integrates with the master transcriptional control of gene expression, in ways that only in the last decade have been increasingly ... -
Angiogenesis in Chronic Obstructive Pulmonary Disease: A Translational Appraisal
(2012)Angiogenesis is a crucial component of lung pathophysiology, not only in cancer but also in other disorders, such as chronic obstructive pulmonary disease (COPD). In COPD angiogenesis is definitely able to control and ... -
Sisters acts: converging signaling between CaMKII and CaMKIV, two members of the same family
(2012)Calcium (Ca2+ ) is a universal second messenger that regulates a number of diverse cellular processes including cell proliferation, development, motility, secretion, learning and memory1, 2. A variety of stimuli, ... -
Pediatric health mobility: is it only an italian problem?
(2012)Intra-regional, extra-regional and international health mobility are important phenomena for regional and national healthcare planning. Pediatric data on this topic are scarce. We therefore conducted a systematic ... -
Minimally invasive swine experimental model for the in vivo study of liver metabolism of drugs
(2012)Purpose: To develop a clinically relevant porcine model for the study of hepatic metabolism of drugs by means of hepatic vein catheterization. Materials and Methods: review of literature and elaboration of a hypothesis, ... -
Breakthrough pain: the importance of baseline analgesic regimen with opioids
(2012)Pain is one of the most common and often most feared symptoms in patients with cancer. Ongoing or progressive pain is physically debilitating and has a marked impact on quality of life. During their illness, at least ... -
Sepsis-associated encephalopathy
(2012)Sepsis-associated encephalopathy (SAE) is defined as a diffuse or multifocal cerebral dysfunction induced by the systemic response to the infection without clinical or laboratory evidence of direct brain infection. Its ...