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Target-based study to identify new bioactive diterpenes
(Universita degli studi di Salerno, 2019-04-16)
Target identification and mechanism of action studies of plant-derived compounds play a critical role in drug discovery. The knowledge of the bioactivity of natural compounds can lead to a number of advantages: first of ...
PGI products of Campania region: chemical and biological investigation of edible parts and by-products as potential sources of functional ingredients for herbal, nutraceutical and cosmetic formulations.
(Universita degli studi di Salerno, 2018-05-05)
This project is addressed to the definition of the chemical profile of selected PGI products of Campania region and related byproducts to highlight the presence of phytochemicals with health benefits. The species studied ...
Design and synthesis of bioactive small molecules by traditional and innovative methods
(Universita degli studi di Salerno, 2018-03-28)
My PhD research plan concerns the exploration of the structural requirements determining TRPM8 modulation. We prepared a series of N-substituted tryptamines and identified two compounds acting, respectively, as an activator ...
The Winnie-APCmin as an innovative tool to investigate the axis between inflammation and colorectal cancer
(Universita degli studi di Salerno, 2019-05-07)
During these last three yeas of PhD we aimed to create a new murine model of spontaneous inflammatory-induced colorectal cancer a combining the genetic susceptibility of the APCMin model and the chronic intestinal inflammation ...
Role of CD73 - A2A/A2B receptors axis in cancer
(Universita degli studi di Salerno, 2018-04-05)
The adenosinergic pathway plays a critical role in cancer development and progression, as well as
in drug resistance to chemotherapy and/or targeted-therapy.
The goal of this PhD thesis was to investigate and fully ...
Computational chemistry techniques for the design and the synthesis of molecules with anti-inflammatory and anti-tumor activity
(Universita degli studi di Salerno, 2019-06-18)
In the last few years, computational chemistry has played an important role in disclosing novel compounds with relevant biological activity. Inflammation and cancer processes have been recently linked, and the identification ...