Sfoglia per Titolo
Items 1261-1280 di 6056
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Design, synthesis and pharmacological studies of structural analogues modeled on bioactive natural products
(Universita degli studi di Salerno, 2011-03-21)Microsomal prostaglandin E2 synthase-1 (mPGES-1) is the enzyme responsible for the conversion of the cyclooxygenase (COX)-derived prostaglandins (PG)H2 into PGE2. This enzyme is deeply involved in different pathologies; ... -
Design, synthesis, biological evaluation and binding studies of new small-molecule modulators of KDMs (lysine-specific demethylases)
(Universita degli studi di Salerno, 2017-03-27)JHDMs (JmjC-domain-containing histone demethylases) are the largest class of demethylase enzymes, contain a Jumonji C (JmjC) domain and catalyze lysine demethylation of histones through an oxidative reaction that requires ... -
Design, synthesis, biological studies of new mitochondrial modulators improving neurological deficits in experimental models of Huntington's disease
(Universita degli studi di Salerno, 2017-03-22) -
Design, virtual screening and structural studies of new molecules with potential antitumor and antiinflammatory activity
(Universita degli studi di Salerno, 2012-03-30)Computational methodologies in combination with experimental techniques as Nuclear Magnetic Resonance (NMR) have become a crucial component in drug discovery process, from hit identification to lead optimization. The study ... -
Designing in-vitro systems to simulate the in-vivo permeability of drugs
(2014)In this work an engineering approach, consisting in an experimental procedure and a model to derive the data, was presented and applied to improve the testing methods of pharmaceuticals. The permeability of several ... -
Designing usable mobile interfaces for spatial data
(Universita degli studi di Salerno, 2012-03-29)This dissertation deals mainly with the discipline of Human-‐Computer Interaction (HCI), with particular attention on the role that it plays in the domain of modern mobile devices. Mobile dev ... -
Destino e libertà nei ‘Dialoghi con Leucò’ di Cesare Pavese: ‘I ciechi’, ‘La strada’
(2021)Nei Dialoghi con Leucò di Cesare Pavese il tema del rapporto tra uomini, dèi e destino costituisce uno dei concetti-chiave dell’opera, ma lega in particolare i dialoghi I ciechi e La strada, che hanno come protagonista ... -
Detailed study of local and regional seismicity recorded by the underground UNDERSEIS array at Gran Sasso (Central Italy)
(Universita degli studi di Salerno, 2011-05-13)In this work I analyzed seismic data recorded by two arrays installed in the area of Mt. Gran Sasso (Central Italy), one located at 1.4 km depth (UNDERSEIS), and the other at surface (Fontari). The aim is to compare the ... -
Detailed study of the 2010-2014 Pollino (Italy) seismic sequence with absorption and scattering imaging of the surrounding area
(Universita degli studi di Salerno, 2020-02-04)A detailed study of the seismic sequence occurred in the western sector of the Pollino Range (Southern Italy) between 2010 and 2014, and an imaging of the surrounding area, have been performed in this thesis. The sequence, ... -
Detecting and indexing moving objects for Behavior Analysis by Video and Audio Interpretation
(Universita degli studi di Salerno, 2014-02-28)In the last decades we have assisted to a growing need for security in many public environments. According to a study recently conducted by the European Security Observatory, one half of the entire population is worried ... -
Detecting subjectivity through lexicon-grammar. strategies databases, rules and apps for the italian language
(Universita degli studi di Salerno, 2016-03-01)The present research handles the detection of linguistic phenomena connected to subjectivity, emotions and opinions from a computational point of view. The necessity to quickly monitor huge quantity of semi-structured and ... -
Determinantes e infraestructuras de la migración: el papel de los mediadores y las redes en migración italiana a Bogotá
(2023)Este artículo presenta algunos resultados de una investigación cualitativa realizada con migrantes italianos en Bogotá, Colombia, en el primer semestre de 2020. Nos centra-mos en los determinantes y las ... -
The determinants of translational medicine success - A managerial contribution
(2013)Scope of Translational Medicine is to speed the development of new compounds of medical protocols and/or treatments to improve patient’s quality of life. Translational medicine represents the synergy between epidemiology, ... -
Determinazione del ruolo della proteina BAG3 nelle isole del Langerhans e suo coinvolgimento nel meccanismo di secrezione dell’insulina
(Universita degli studi di Salerno, 2015-04-22)Diabetes is a metabolic alteration due to a decrease in activity of insulin. In particular, it may be a consequence of a reduced availability of this hormone, of an impediment to its normal action, or of a combination ... -
Developing an InnovativeBlockchain-basedModel to Contribute to the Implementation of the 2030 Agenda in Italy
(Universita degli studi di Salerno, 2022-05-09)One of the most crucial collective efforts in history for improving the lives of billions of people is Sustainable Development Goals (SDGs). The aim of the seventeen (SDGs) s included in the 2030 agenda represents the ... -
Development and Evaluation of Innovative Stationary Phases for Separation of Pharmaceuticals, Metabolites and Biocompounds
(Universita degli studi di Salerno, 2020-09-18)Biofluids are typical complex matrices representing a source of potential biomarkers, but often require high demands in sample preparation prior to analysis. With this purpose, several techniques have been developed ... -
Development and experimental validation of CPOx reforming dynamic model for fault detection and isolation in SOFC systems
(Universita degli studi di Salerno, 2015-06-13)In the present work an investigation of the reforming technologies available for Solid Oxide Fuel Cell (SOFC) systems and their basic concepts has been carried out, with the aim to describe, test and simulate the reforming ... -
Development and optimization of analytical methods for the analysis of drugs in wastewater samples and chronic aquatic toxicity assessment of the Crustacea Copepoda Tigriopus fulvus
(Universita degli studi di Salerno, 2020-02-13)Pharmaceutical compounds constitute one of the most important emerging classes of environmental pollutants. Recent studies have discovered their occurrence in environmental samples investigated worldwide, including ... -
Development and optimization of Electrochemical Affinity Biosensors for the control of food safety
(Universita degli studi di Salerno, 2018-06-01)The guarantee of food safety requires a fast and accurate control for all chemicals and bacteria, which are harmful for human health. In the food industry, the safety of a product is evaluated through periodic chemical ...