Sfoglia per Titolo
Items 1273-1292 di 6050
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The determinants of translational medicine success - A managerial contribution
(2013)Scope of Translational Medicine is to speed the development of new compounds of medical protocols and/or treatments to improve patient’s quality of life. Translational medicine represents the synergy between epidemiology, ... -
Determinazione del ruolo della proteina BAG3 nelle isole del Langerhans e suo coinvolgimento nel meccanismo di secrezione dell’insulina
(Universita degli studi di Salerno, 2015-04-22)Diabetes is a metabolic alteration due to a decrease in activity of insulin. In particular, it may be a consequence of a reduced availability of this hormone, of an impediment to its normal action, or of a combination ... -
Developing an InnovativeBlockchain-basedModel to Contribute to the Implementation of the 2030 Agenda in Italy
(Universita degli studi di Salerno, 2022-05-09)One of the most crucial collective efforts in history for improving the lives of billions of people is Sustainable Development Goals (SDGs). The aim of the seventeen (SDGs) s included in the 2030 agenda represents the ... -
Development and Evaluation of Innovative Stationary Phases for Separation of Pharmaceuticals, Metabolites and Biocompounds
(Universita degli studi di Salerno, 2020-09-18)Biofluids are typical complex matrices representing a source of potential biomarkers, but often require high demands in sample preparation prior to analysis. With this purpose, several techniques have been developed ... -
Development and experimental validation of CPOx reforming dynamic model for fault detection and isolation in SOFC systems
(Universita degli studi di Salerno, 2015-06-13)In the present work an investigation of the reforming technologies available for Solid Oxide Fuel Cell (SOFC) systems and their basic concepts has been carried out, with the aim to describe, test and simulate the reforming ... -
Development and optimization of analytical methods for the analysis of drugs in wastewater samples and chronic aquatic toxicity assessment of the Crustacea Copepoda Tigriopus fulvus
(Universita degli studi di Salerno, 2020-02-13)Pharmaceutical compounds constitute one of the most important emerging classes of environmental pollutants. Recent studies have discovered their occurrence in environmental samples investigated worldwide, including ... -
Development and optimization of Electrochemical Affinity Biosensors for the control of food safety
(Universita degli studi di Salerno, 2018-06-01)The guarantee of food safety requires a fast and accurate control for all chemicals and bacteria, which are harmful for human health. In the food industry, the safety of a product is evaluated through periodic chemical ... -
Development and validation of analytical methods for therapeutic drug monitoring
(Universita degli studi di Salerno, 2019-07-25)The U.S. Food and Drug Administration defines as Precision or Personalized Medicine (PM) an innovative therapeutic approach that tailors therapy and prevention on patients based on inter-individual variabilities in ... -
Development of a bioengineered three-dimensional scaffold able to commit stem cells toward tenogenic phenotype
(Universita degli studi di Salerno, 2021-06-23)The term tendinopathy is a generic descriptor of tendon disorders. Spontaneous adult tendon healing results in scar tissue formation and fibrosis, with impaired biological and mechanical properties. Adult tendons have ... -
Development of a Human Reliability Analysis (HRA) model for break scheduling management in human-intensive working activities
(Universita degli studi di Salerno, 2018-03-07)Human factors play an inevitable role in working contexts and the occurrence of human errors impacts on system reliability and safety, equipment performance and economic results. If human fallibility contributes to majority ... -
Development of a model-based diagnosis algorithm oriented towards solid oxide fuel cell systems: approach and application
(Universita degli studi di Salerno, 2014-07-07)The present dissertation illustrates the complete procedure of developing a model-based diagnosis algorithm and shows its application to a pre-commercial Solid Oxide Fuel Cell (SOFC) system. The main motivations of this ... -
Development of a versatile screening platform for the identification of small-molecule ligands for reader proteins of the post-translational methylation
(Universita degli studi di Salerno, 2021-06-25)Covalent Post Translational Modifications (PTMs) of histone proteins are introduced and removed by the ‘writer’ and ‘eraser’ enzymes, respectively. These modifications are recognized by highly specific binding domains, ... -
Development of an adaptive hierarchical multi-scale approach for the assessment, planning and prevention of the impact on anthropic and natural environments due to the exceeding of radon gas concentrations above threshold values and the corresponding risk associated to indoor radon exposures
(Universita degli studi di Salerno, 2018-04-17)With its publication, the Directive not only acknowledges the latest international research results but reopens the scientific panorama of the control and monitoring of Radon concentrations, which had a period of stasis ... -
Development of analytical methodology for determination of emerging contaminants in enviroment and food
(Universita degli studi di Salerno, 2015-04-24)In recent years, fate, occurrence and potential adverse effect of emerging contaminants (ECs) in the environment have received an increased attention by scientific community. The ECs are a broad category of chemicals, ... -
Development of analytical strategies for phytochemical investigation of «superfoods», with particular attention to Botanicals.
(Universita degli studi di Salerno, 2022-04-27)There is a great attention to functional foods exerting health benefits. In this frame the claim ‘superfood’ to characterize products with high nutritional value and bioactive phytochemicals is more and more used. In ... -
Development of dosimeters with selective materials to high frequency radiation
(Universita degli studi di Salerno, 2013-01-23)The clinical use of ionizing radiation to obtain a necrosing or cytotoxic radiobiological effect on tumoral lesions requires wide and complex physical and dosimetrical procedures. In particular, it is necessary to calculate ... -
Development of eco-sustainable methodologies for innovative materials inspired by cellulose fibers
(Universita degli studi di Salerno, 2021-04-28)This PhD is an “Industrial-PhD”, carried out in collaboration between University of Basilicata and LUCART S.p.A (Porcari, Lucca, Italy), in that case with the plant located at Avigliano (Potenza, Italy). The scholarship ... -
Development of iron-based catalysts for the coupling of carbon dioxide with epoxides
(Universita degli studi di Salerno, 2018-03-07)Beside the environmental and energetic issues, carbon dioxide can be considered as a resource. Many chemical transformations based on CO2 as C-1 building block have been developed. The coupling reaction of epoxides with ... -
Development of molecular models of interfaces using a multi-scale hybrid particle-field approach: application to composite materials and biomembranes
(Universita degli studi di Salerno, 2014-03-07)The rule of the interface in systems including polymer composites and block-‐ copolymer interacting with biomembrane has been investigated by computational approach. In particular, for the poly ... -
Development of new in vitro models based on the use of electrospun scaffolds and their imaging by multiphoton microscopy coupled with fluorescence lifetime imaging microscopy
(Universita degli studi di Salerno, 2018-02-22)In this thesis, new possible applications of electrospun scaffolds are presented. Besides, the interaction of human dermal fibroblasts (HDFs) with the materials has been investigated using multiphoton microscopy (MPM) ...