Browsing by Title
Now showing items 732-751 of 3681
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Design and development of new polymeric materials with potential antimicrobial and/or antifungal activity
(Universita degli studi di Salerno, 2014-12-15)This PhD project is focused on the development of new polymeric materials with antibacterial and antifungal activity. The first part of the work was dedicated to the synthesis and the insertion of a modified amino acid ... -
Design and optimization of a protection device for laser weld beads of metal alloys for aerospace applications
(Universita degli studi di Salerno, 2013-09-09)In the present thesis an automated laser welding apparatus was designed and developed in order to perform laser , that allows to achieve laser welding in a controlled, versatile, efficient, reliable, simple, and economical ... -
Design and structural optimization of new molecules as potential antiinflammatory and/or anticancer agents.
(Universita degli studi di Salerno, 2015-03-10)L’infiammazione ed il cancro sono due complessi meccanismi patologici in cui risultano coinvolti una serie di differenti mediatori molecolari. La profonda connessione tra cancro ed infiammazione è ben nota e la modulazione ... -
Design and synthesis of bioactive small molecules by traditional and innovative methods
(Universita degli studi di Salerno, 2018-03-28)My PhD research plan concerns the exploration of the structural requirements determining TRPM8 modulation. We prepared a series of N-substituted tryptamines and identified two compounds acting, respectively, as an activator ... -
Design and synthesis of modulators of apoptotic activity
(Universita degli studi di Salerno, 2016-03-23)p53 is a transcription factor with tumour suppressor properties, which is able to induce mitochondrial apoptosis independently of its transcriptional activity. Analogues of the spiro[imidazo[1,5-c] thiazole-3,3′-indoline] ... -
Design and synthesis of new integrase inhibitors
(Universita degli studi di Salerno, 2017-03-28)The viral enzyme integrase (IN) is essential for the replication of human immunodeficiency virus type 1 (HIV-1) and represents an important target for the development of new antiretroviral drugs. In this PhD project, we ... -
Design and synthesis of new polycyclic compounds with potential anticancer activity
(Universita degli studi di Salerno, 2011-02-21)p53 is best known as a tumor suppressor that transcriptionally regulates, in response to cellular stresses such as DNA damage or oncogene activation, the expression of various target genes that mediate cell-cycle arrest, ... -
The design and synthesis of novel N-heterocyclic compounds, and their evaluation of anti-cancer and anti-viral activity
(Universita degli studi di Salerno, 2014-05-21)The thesis entitled “The design and synthesis of novel N-heterocyclic compounds, and their evaluation of anti-cancer and anti-viral activity" is divided into three chapters. The title of the thesis clearly reflects the ... -
Design and synthesis of peptides involved in the inhibition of influenza virus infection
(Universita degli studi di Salerno, 2017-03-28)The main purpose of the present research project was the identification of peptide capable of exercising potent anti-influenza activity. We identified bovine lactoferrin (bLf) as drug target, a multifunctional glycoprotein ... -
Design and synthesis of peptides that modulate apoptotic process.
(Universita degli studi di Salerno, 2014-11-17)Oncogenic activation of tyrosine kinases is a common feature in cancer, and its regulation represents an excellent antitumoral target. Tyrosine phosphorylation is also controlled by protein-tyrosine phosphatases (PTPs). ... -
Design and synthesis of “small molecules” as antiviral and radiotracer agents
(Universita degli studi di Salerno, 2011-03-28)The present Ph.D. project was divided into different work parts, in a way that helps to understand and define the goals of this project. In particular: I) Design, synthesis and evaluation of antiviral activity of Arbidol ... -
Design e sintesi di analoghi delle azumammidi, potenti inibitori degli enzimi HDACs
(Universita degli studi di Salerno, 2011-03-07)Le azumammidi sono cinque ciclopeptidi di origine marina, isolate nel 2003 da Fusetani et al dalla spugna Mycale izuensis e brevettate dalla Yamanouchi Pharmaceutical. L'interesse destato da questi metaboliti secondari ... -
Design, synthesis and biological activity of new target selective antitumoral agents
(Universita degli studi di Salerno, 2018-04-05)Cancer development is a complex pathological process that exploits a variety of biological actors. The identification of new molecular entities able to interfere with new biological targets, involved in tumorigenesis, is ... -
Design, synthesis and biological evaluation of new anticancer and/or anti-inflammatory agents
(Universita degli studi di Salerno, 2017-03-22)One of the main goal of modern medicinal chemistry is the development of new agents able to modulate biological targets involved in inflammation and cancer processes. In this context, my PhD project was focused on the ... -
Design, synthesis and biological evaluation of new non-nucleosidic inhibitors od DNA methyltransferases
(Universita degli studi di Salerno, 2013-04-03)The inactivation of tumor suppressor genes, which often results from epigenetic silencing associated with DNA hypermethylation, plays a pivotal role in the development of most forms of human cancer. Moreover, there are ... -
Design, synthesis and biological evaluation of new small molecule modulators of Arginine methyltransferases
(Universita degli studi di Salerno, 2011-02-21)The methylation of arginine residues is a prevalent post-translational modification, found on both nuclear and cytoplasmic proteins, catalyzed by the protein arginine N-methyltransferase (PRMT) family of enzymes. To date ... -
Design, synthesis and biological evaluation of new small molecules with anti-inflammatory activity
(Universita degli studi di Salerno, 2015-03-18)Per lipossigenasi (nota più comunemente con l'abbreviazione di LOX o LO) si intende una famiglia eterogenea di enzimi in grado di perossidare i lipidi e di causare l'ossigenazione di acidi grassi polinsaturi trasformandoli, ... -
Design, synthesis and biological evaluation of new small-molecule modulators of proein lysine methyltransferases (PKMTs)
(Universita degli studi di Salerno, 2018-04-20)Histone lysine methyltransferases have crucial roles in a number of biological processes and human diseases by controlling gene expression and chromatin state. Within this family, the lysine methyltransferase G9a has emerged ... -
Design, synthesis and biological evaluation of new small-molecule modulators of Protein Methyltransferases (PMTs)
(Universita degli studi di Salerno, 2016-04-21)A large amount of evidences indicate that dysregulation of protein methylation is linked to the genesis and progression of several human diseases, including cancer. Therefore over the past years small-molecule modulators ... -
Design, synthesis and biological studies of novel heterocyclic compounds as anticancer drugs
(Universita degli studi di Salerno, 2015-04-24)Heterocyles are an essencial class of molecules, assuming a role in many aspect of our life. Indeed heterocyclic nucleus is a common feature of several biomolecule and bioactive compounds including agrochemical products ...
