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Design and synthesis of modulators of apoptotic activity
(Universita degli studi di Salerno, 2016-03-23)
p53 is a transcription factor with tumour suppressor properties, which is able to induce mitochondrial apoptosis independently of its transcriptional activity. Analogues of the spiro[imidazo[1,5-c] thiazole-3,3′-indoline] ...
Design, synthesis and biological evaluation of new anticancer and/or anti-inflammatory agents
(Universita degli studi di Salerno, 2017-03-22)
One of the main goal of modern medicinal chemistry is the development of new agents able to modulate biological targets involved in inflammation and cancer processes. In this context, my PhD project was focused on the ...
Synthesis, characterization and cytotoxicity studies of novel organo-metallic compounds
(Universita degli studi di Salerno, 2015-04-24)
Despite the discovery of cis-platin in the treatment of cancer there has
been a considerable exploration on the antitumoral activity of other
transition metal complexes. One of the main problems about the
application ...
In vitro effects of bioactive extracts of local Italian cultivars: from molecular mechanisms to potential nutraceutical applications for consumers’ well-being
(Universita degli studi di Salerno, 2017-03-31)
Phytochemicals are non-nutritional compounds, naturally present in food and beverages, which exert
beneficial effects on human health. The present Doctorate Thesis evaluates the biological properties
of bioactive ...
Design, synthesis and biological evaluation of new small-molecule modulators of proein lysine methyltransferases (PKMTs)
(Universita degli studi di Salerno, 2018-04-20)
Histone lysine methyltransferases have crucial roles in a number of biological processes and human diseases by controlling gene expression and chromatin state. Within this family, the lysine methyltransferase G9a has emerged ...
Design and synthesis of peptides involved in the inhibition of influenza virus infection
(Universita degli studi di Salerno, 2017-03-28)
The main purpose of the present research project was the identification of peptide capable of exercising potent anti-influenza activity. We identified bovine lactoferrin (bLf) as drug target, a multifunctional glycoprotein ...
Design, synthesis and biological studies of novel heterocyclic compounds as anticancer drugs
(Universita degli studi di Salerno, 2015-04-24)
Heterocyles are an essencial class of molecules, assuming a role in many aspect of
our life. Indeed heterocyclic nucleus is a common feature of several biomolecule and
bioactive compounds including agrochemical products ...
Design, synthesis, biological evaluation and binding studies of new small-molecule modulators of KDMs (lysine-specific demethylases)
(Universita degli studi di Salerno, 2017-03-27)
JHDMs (JmjC-domain-containing histone demethylases) are the largest class of demethylase enzymes, contain a Jumonji C (JmjC) domain and catalyze lysine demethylation of histones through an oxidative reaction that requires ...
Design and synthesis of new integrase inhibitors
(Universita degli studi di Salerno, 2017-03-28)
The viral enzyme integrase (IN) is essential for the replication of human immunodeficiency virus type 1 (HIV-1) and represents an important target for the development of new antiretroviral drugs. In this PhD project, we ...
NMR-based metabolomic analysis of biological fluids to monitor relevant unsolved diseases
(Universita degli studi di Salerno, 2017-03-30)
Metabolomics and metabonomics encompass the comprehensive profiling of multiple metabolite
concentrations and their cellular and systemic fluctuations in response to drugs, diet, lifestyle,
environment, stimuli and genetic ...